Applied BioPhysics, Inc. applies the results of biophysical research to provide practical tools for cell research and drug discovery.
ECIS™ or Electric Cell-substrate Impedance Sensing is an impedance based method to study many of the activities of animal cells when grown in tissue culture in real-time. These include morphological changes, cell locomotion, and other behaviors directed by the cell's cytoskeleton. ECIS™ technology was invented by Drs. Ivar Giaever and Charles R. Keese while working at General Electric Corporate Research and Development, but its commercial potential was not explored as it fell outside of GE's core interests. In 1991, as the applications of the technology became more apparent, Drs Giaever and Keese formed Applied BioPhysics, Inc. as a private company to develop, commercialize and market ECIS™ and other biophysical technologies. Applied BioPhysics is located next to the Rensselaer Polytechnic Institute campus, where several collaborative research projects are ongoing in the academic laboratories.
Since the formation of the company, the ECIS™ approach has been applied to numerous investigations including measurements of the invasive nature of cancer cells, the barrier function of endothelial cells, in vitro toxicity testing as an alternative to animal testing, and signal transduction involving GPCR's for modern drug discovery.
Instruments are located throughout the United States as well as in Asia and Europe. Customers include Johns Hopkins University, The University of Tokyo, Vanderbilt University, Brown University, Genentech, and Allergan to mention a few. Drs. Giaever and Keese continue to develop new innovations to enhance the ECIS technology including most recently an automated wound healing assay and a device to study the behavior of cells under flow conditions both of which are now commercially available.
Charles R. Keese, President, holds a BS in physics and a Ph.D. in biology and is the author of numerous technical papers and patents. While a staff scientist at the General Electric Research and Development Center, in addition to co-inventing the ECIS technology, he was involved in the development of the indium slide immunoassay and the use of fluorocarbon fluids as substrates for cell growth culminating in the first liquid microcarrier.
The company's Chief Technology Officer, Ivar Giaever, is a highly recognized physicist who shared the 1973 Nobel Prize in Physics for his studies of tunneling and superconductivity. He then became interested in biophysics, in particular, the behavior of macromolecules and cells on metal films.
Christian Dehnert, Vice President Marketing, holds a BS and MS in electrical engineering and a MBA with an industrial marketing focus. He has over 16 years of experience in the marketing and sales of high technology products.
Catherine received her BS in Biology from Rensselaer Polytechnic Institute. Prior to working for Applied BioPhysics she completed an internship at Albany Medical College. She will be consulting with researchers to match ECIS technology with their individual needs and goals.
Michael received his MS in Molecular Biology and BS in Human Biology at Boise State University. During his collegiate years, he also gained extensive experience in business and sales at a local retail company. He will serve to provide research labs with ECIS® technologies to aid in their novel discoveries.
Applied BioPhysics manufactures ECIS™ (Electric Cell-Substrate Impedance Sensing) instruments and arrays for monitoring the behavior of cells in tissue culture. We not only pride ourselves for being the founders of an automated, quantitative, real-time instrument, we also pride ourselves on being as academic minded as we are business savy. Our primary intention is to provide an instrument that answers the researchers experimental question(s). A system sitting idle is as much of a loss to you as it is to our company.
We thrive on creating a strong ECIS™ community, a network between ECIS™ users, and with Applied BioPhysics. We rely heavily on peer reviewed publications to learn about how ECIS is being used for various applications. In turn we are able to connect ECIS™ users with one another when questions arise about specific assays, cell lines, experimental conditions, and protocols.
We have a dedicated team of employees that make our customers and their research a priority. It is not uncommon for us to make ourselves available after hours when researchers have questions, or need assistance.
All of our products are manufactured in the USA, 95 percent of which are manufactured at our facility in Troy, NY.
Applied BioPhysics, Inc. has a mission to bring you innovative technology to benefit your research, with guaranteed satisfaction through manufacturing and person to person communication. Reliable, reproducible, and real-time results are our universal approach to the cell-science community.
Applied BioPhysics is dedicated to minimizing its environmental impact, and ensuring a sustainable future by finding opportunities within both its operations and business practices to promote environmentally sound choices.
Applied BioPhysics is developing innovative solutions to bring about change by:
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Dave Litwiller is a senior executive of DALSA Corporation, headquartered in Waterloo, Ontario, Canada. He oversees strategy and market development for DALSA's business units in semiconductor fabrication, image sensor integrated circuit development, MEMS, digital cinema and life sciences instrumentation. In previous roles with DALSA, Mr. Litwiller was the head of marketing, and before that, the head of engineering. Prior to joining DALSA, Mr. Litwiller was a design engineer at several high technology start-ups in the wireless, fiber optic telecom, and broadcast industries.
Mr. Litwiller is a graduate of the University of Waterloo, and holds a Bachelor of Applied Science degree. He serves as an advisor for various private corporations in matters of strategy, technology, and business development. Mr. Litwiller is a frequent speaker at technology start-up forums and executive industry association conferences on business strategy.
Joachim Wegener is a professor for Biosensors & Bioanalytics at the University of Regensburg in Germany where he moved in 2008 from his previous appointment at the University of Muenster (Germany). He holds a diploma in chemistry and received his PhD from the University of Muenster in 1998. His research interests are focussed on the development of non-invasive whole-cell biosensors that can be applied to follow the behaviour of mammalian cells in vitro. As the analysis of living systems is a complex task, Wegener’s research aims to bring together several sensoric principles in one device (multi-parametric sensing) so that more than one parameter can be recorded from a given cell population simultaneously. He has authored numerous research papers, book chapters and review articles on this subject. Wegener teaches courses in biochemistry, cell biology, biosensors & bioanalytics at the undergraduate and graduate level.
Joachim Wegener started to work with ECIS and related techniques in 1993 inspired by the publications of Ivar Giaever and Charles Keese, the founders of Applied BioPhysics Inc. After having received his PhD, he joined the Giaever lab for two years working as a postdoc with Giaever & Keese on cell adhesion, electroporation and cell wounding - all based on the ECIS technology. Since this time he has strong interest in modeling and simulating the electrical properties of living animal cells on conducting surfaces and developing new applications for the ECIS technology.
Professor Chu Ming Lo of Yang Ming University of Taiwan leading a session on ECIS Theory during a customer training course at Shanghai Technical University
The ECIS training course was given in cooperation between Dakewe and Sunpoint and allowed for ECIS training in Chinese. ECIS training courses have taken place in Troy, NY, Munich, Germany, Taipei, Taiwan and most recently Shanghai, China. For inquiries as to the next ECIS training course please contact Applied BioPhysics or the distributor nearest you.
The annual conference of Korea Federation of Women's Science and Technology Association (KOFWST) was held on November 14, 2014 in Seoul, Korea with the theme "Women Scientist and Engineers Lead the World".
Dr. Ivar Giaever, Chief Technology Officer of Applied BioPhysics, Inc. who won the Nobel Prize in Physics in 1973 was guest speaker.