November 1, 2003
The ECISTM (Electric Cell-substrate Impedance Sensing) method to detect morphological changes of cells in culture via impedance measurements can also be used to detect and monitor the activation of G-protein-coupled receptors. Studies of activation of both muscarinic and beta adrenegic receptors resulted in large reproducible impedance changes; these changes were blocked with the appropriate antagonist and the response studies returned proper EC50 values. As a whole-cell biosensor for drug discovery, this approach can be used not only to detect receptor activation, but will also return information regarding the toxicity of test compounds.
Applied BioPhysics was founded by two researchers from General Electric Research and Development Center, Charles Keese, PhD in biology, and Ivar Giaever, PhD in physics. In 1973, Dr. Giaever received the Nobel Prize in Physics.
Applied BioPhysics develops and manufactures instrumentation for non-invasive measurement of cells. Applied BioPhysics products are sold worldwide.