Troy, NY, July 15, 2002…… Applied BioPhysics Inc. offers a new fully automated instrument to monitor cell behavior, the Model 1600R. Using standard tissue culture methods and media, one can electrically monitor cell morphological changes continuously and in real time. The system can follow up to 16 independent culture wells. Applications include measurements of cell-integrin interactions, signal transduction, in vitro toxicology, metastatic potential, cell motility, proliferation and migration.
ECIS is being used to monitor cell-ECM interactions and readily follows the dynamics of cell spreading and proliferation. One of the most common uses for ECIS is the time course determination of barrier function changes for endothelial cell layers in vitro.
The ECIS system can be used to monitor the binding of agonists to GPCR’s. Regardless of the second messenger involved, most signal transduction cascades ultimately results in changes of cell morphology – readily detected with the ECIS instrumentation. The measurement has been demonstrated to monitor cell response upon binding of agonists to the muscarinic receptor in CHO cells. ECIS also offers a quantitative in vitro method to discern the metastatic potential of cancer cells.
Applied BioPhysics was founded by two researchers from the General Electric Research and Development Center, Charles Keese whose Ph.D. is in biology, and Ivar Giaever, Ph.D. in physics. Dr. Giaever received the 1973 Nobel Prize for Physics.
Applied BioPhysics develops and manufactures instrumentation for non-invasive measurement of cells. Applied BioPhysics products are sold worldwide.