Troy, NY, May 11, 2001…… Applied BioPhysics Inc. offers a new automated method to monitor cell behavior. Using standard tissue culture methods and media, one can electrically monitor cell morphological changes continuously and in real time. The system can simultaneously follow up to 16 independent culture wells. Applications include measurements of cell-integrin interactions, signal transduction, in vitro toxicology, metastatic potential, cell motility, proliferation, and migration.
ECIS is being used to monitor cell-ECM interactions and readily measures the dynamics of cell spreading and proliferation.
The ECIS system can be used to monitor the binding of agonists to GPCR’s. Regardless of the second messenger involved, most signal transduction cascades ultimately result in changes in intracellular calcium ion concentrations, and this in turn alters cell morphology – readily detected with the ECIS instrumentation.
One of the most common uses for ECIS is the time course determination of the barrier function of endothelial cell layers in culture. When these layers are challenged by transformed cells, ECIS measurements offers a quantitative in vitro method to discern the metastatic potential of cancer cells.
Applied BioPhysics was founded by two researchers at General Electric Research and Development Center, Charles Keese whose Ph.D. is in biology, and Ivar Giaever, Ph.D. in theoretical physics. Dr. Giaever received the 1973 Nobel Prize for Physics.
Applied BioPhysics develops and manufactures instrumentation for non-invasive measurement of cells. Applied BioPhysics products are sold worldwide.